The pictured error can occur when trying to launch Big Business Server for Windows, from its Shortcut, as an Application, when it is already running as a Windows Service.
To avoid this problem, Stop the Service before attempting to run as an Application. When this problem occurs, the fix is to Restart the computer, then Stop the Service.
Big Business Server can be set to run as a Service in Windows Server to automate start.
Test the new Service by click Start in Services to see if the Service immediately stops. If so it may have Permissions issue which you can resolve by setting the Service to use the same Account that allows you to run it as an application and stores your settings.